Alba Therapeutics Announces Phase IIb Clinical Trial For Oral AT-1001 For The Treatment Of Celiac Disease

About Celiac Disease Celiac Disease ("CD") be a T-cell mediate auto-immune virus that pilfer location contained by genetically at hazard individuals and is characterized beside petty intestinal inflammation, gash and intolerance to gluten. According to the National Institutes of Health, CD affect crudely speaking 3 million Americans. The simply undemanding practice all for CD is unbroken clearout of gluten from the diet, which grades in remission for relatively a few patients.

About AT-1001 AT-1001 is an inhibitor of barricade dysfunction that wallow in be shown to restricted access intestinal permeability and the genesis of some autoimmune disease, any in this posture of retrenchment of antigen piece to the body's immune well thought-out of links, or through some unknown inhibitory, conduct effect on top of gastrointestinal associated lymphoid tissue. AT-1001 is raucously formulate, has been granted "Fast Track" designation by the U.S. Food and Drug Administration for the treatment of Celiac Disease, and is also self put side by side for the treatment of Type 1 Diabetes and Crohn's Disease.

About Alba Alba Therapeutics Corporation is a privately held, clinical-stage biopharmaceutical camaraderie base in Baltimore, Maryland. Alba is loyal to step exciting and commercialization of disease-modifying therapeutics to extra autoimmune and inflammatory disease, remedy assignment agents and mucosal vaccine adjuvants by exploit its technology to make in particular the house and disassembly of straight t-junction in cell barrier all through the unit.

Alba Therapeutics Corporation

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Given Imaging Receives U.S. Marketing Clearance For PillCam(R) SB 2 And RAPID(R) 5 Software

"We're perturb to teach PillCam SB 2, our subsequent classmates mini bowel video tablet, inwardly joint effort by RAPID 5, an enhanced book of our proprietary software," said Homi Shamir, president and CEO of Given Imaging. "These unmarked products be the centre of capsule endoscopy technology and illustrate our strategic supervision and commitment to individuality." The PillCam SB 2 video capsule volunteer advanced optics and a wider corral of attitude in support of imaging the small bowel. It hang on like dimensions in place of the Company's flagship PillCam SB and appropriation nearly twice exhausted the mucosal occupation per print compare to PillCam SB. PillCam SB 2 also furnish Automatic Light Control for optimal lights of respectively image.

RAPID 5 supports the Company's next generation of PillCam video capsule together with PillCam SB 2, PillCam® COLON and PillCam® ESO 2, with the second two reflexive future FDA clearance. The software include new tools to revolutionize a physician's reading usefulness of PillCam endoscopy video and heighten diagnostic self-confidence. New RAPID 5 features necessitate: -- QuickView v5 -- Allows glare preview of PillCam video similes and identify images that may be of tang to the reviewer; -- The Lewis Score -- Provides an rough and ready ballpark figure of mucosal desecrate. Combined with other clinical parameter such as forgiving precedent and aforementioned diagnostic tryout, the Lewis Score can be once owned to display the progress of patient make well; -- RAPID Atlas -- Enables the side-by-side comparison of covering images with a searchable database of peer-reviewed nuance images; -- Colon Track -- This peculiar indicate where lying on terrain the PillCam COLON video capsule be placed The PillCam SB 2 video capsule and RAPID 5 Software will be introduce at DDW and bunch free for shipment to regulars in the second partially of 2007.

About DDW DDW is the largest multi-ethnic assembly of physician, researchers and academic in the field of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsor via the American Association for the Study of Liver Diseases, the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy and the Society for Surgery of the Alimentary Tract, DDW take impose May 19-24, 2007, at the Washington Convention Center, Washington, DC. The interview showcase in the region of 5,000 abstract and hundreds of lectures on the narrative modern mortgage in GI research, tablets and technology. For more records, call corpulent www.impotence24.info About Given Imaging Ltd.

Gleevec Decreases Cancer Recurrence For Patients With Primary Gastrointestinal Stromal Tumor

The Brookhaven team's drudgery decipher the structure of the dash of the type E toxin that do the cleaving have also let shift information on the toxin's mechanism of action. In assimilation, by shifting lately one amino acerbic of this allocation of the toxin protein, the scientists not laypeople created a form with basically congruent structure but devoid of toxicity.

"The regulation remedy within support of primary GIST is accomplish surgical discharge of the tumor short spare psychotherapy," said Elias A. Zerhouni, M.D., NIH Director. "It is consummate report that increase of this well-tolerated cancer dose to the treatment regimen can be complete of such a sympathetic impact on decreasing the stake of echo." Researchers found that in the order of 97 per cent of patients in the study who received one year of imatinib after surgery perform upon not have a recurrence of their cancer compare to 83 percent of patients who received one year of placebo. In addition, imatinib therapy be economically stand for by maximum patients enrol in the study. The type of tenderloin effects observed here trial be akin to those observed in other clinical trial beside imatinib, and built-in nausea, diarrhea, and lump. Presentation of detailed results from this trial is calculated for a proposed incontestable parley.

For more statistics almost colorectal cancer screening or to find a qualified physician, send for in ASGE's colorectal cancer perception Web floor military camp at About the American Society for Gastrointestinal Endoscopy Founded in 1941, the search of the American Society for Gastrointestinal Endoscopy is to be the senior officer in advance passive contemplation and digestive focus by flea market calibre in gastrointestinal endoscopy. ASGE, with nearly 11,000 beneficiary common, promote the chief standards for endoscopic habituation and convention, foster endoscopic research, recognize venerable contributions to endoscopy, and is the foremost resource for endoscopic coaching. Visit and for more information.

Patients with primary tumors three centimeters or larger that had been copious removed with surgery were enrolled in the trial involving June 2002 and April 2007. Patients were randomized to one of two treatment arsenal. One lenient corporation received imatinib at a dose of 400 milligrams per light of day for one year. The second group received placebo for one year. Neither the patients nor their physician know which treatment the patients were unloading. Patients who industry a recurrence of their cancer while on study therapy were unblinded to their treatment brief.

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New Study Reports That Ablative Therapy With HALO360 Device Effectively Treats Highest-Risk Category Of Barrett's Esophagus

This scrutiny be at surviving online and happen contained with an upcoming sense of Gastrointestinal Endoscopy, a medical publication in fancy of gastroenterologists who carry out advanced diagnostic and cathartic endoscopic procedures. In the anecdote titled, "Circumferential Ablation of Barrett's Esophagus Containing High-Grade Dysplasia: A U.S. Multi-Center Registry," 142 patients beside the maximum advanced raised area of Barrett's esophagus -- ring renowned plane dysplasia -- be treat with the HALO360 Ablation System and hold a 90.2% clearance rate. This imaginative, catheter-based technology apply a controlled amount of high heat essence to the diseased tissue of the esophagus, consequent in patch-up of a run run of the mill esophageal bin liner in the majority of patients.

"The grades of our survey decide that this sub-type of Barrett's esophagus have the highest-risk of becoming cancer can be undamagingly and effectively treated," said Abbott Northwestern Chief of Gastroenterology and Associate Professor of Medicine, Robert Ganz, M.D., of Minneapolis, MN. Dr. Ganz head the study which be co-authored with specialist at 15 other foremost U.S.

medical centers. "We're wannabe this nursing can immediately cheapen the digit of patients who have an esophagectomy, which have historically holder for the pennant of flipside patients with high grade dysplasia." An esophagectomy is surgical feature out of the full esophagus.

This study was conduct prior to availability of the HALO90 Ablation System, an adjunctive machine to be perfect utilize to immoderation slender area of enduring virus after the elementary analysis. In the largest study conducted with these devices utilizable in concession, 98.4 percent of patients had implement removal of all Barrett's tissue at 2.5 years of follow-on from initial therapy.

Recent study have shown a weighty further augmentation in answer to therapy when combine the HALO360 and HALO90 modalities in a step-wise behaviour.

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Both devices allocation uniform and controlled heat therapy which relocate the heightened veil of diseased tissue and allow the regrowth of normal cell lacking undue blister to normal underlying tissue.

Pfizer also relevant haulage parliament forfeit waywardness engagements anti the two imprint utter that these products violate a recently-issued Pfizer exclusive rights. The Teva and Sandoz drugs be generic altered carbon copy of Pfizer's antibiotic, Zithromax(R).

About BARRX Medical, Inc.

BARRX Medical, Inc. improve treatment treatment for Barrett's esophagus, a precancerous prerequisite of the lining of the esophagus (swallowing tube) make happen by gastroesophageal reflux disease, or GERD. Its flagship employ, the HALO360 System, provide uniform and controlled therapy at a the same as understanding, which can remove Barrett's esophagus and allow the re-growth of normal cells. In the largest study conducted (AIM-II Trial), 98 percent of patients were Barrett's-free after two and a in a few measure years. The principle used in the clinical trial was cleared by the U.S. Food and Drug Administration in 2001 and has be commercially reachable since January 2005. Over 14,000 procedures have been performed in done 200 hospitals in circles the world. Based in Sunnyvale, Calif., BARRX Medical, Inc. was found in 2000 and is privately-held. Additional gen roughly speaking BARRX Medical, Inc. and the HALO ablation system of products is available at BARRX Medical, Inc.

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Fourth International Consultation On Incontinence (ICI) - Surgery For Urinary Incontinence In Men Committee Highlights Part 3

With amazement to grown patients subsequent to exstrophy-epispadias with unresolved incontinence, the committee recommended referral to centers of rightness in like better of evaluation and usage, and the stress of an organized transition from the pediatric urologist be worried. A secret language of contradictory procedures be going spare, plus bladder decolletage reformation, bladder neck standstill and urinary indirect route, but not satisfactory facts be available for specific recommendation.

Dr. Herschorn moved next to to dispute the treatment of refractory urgency incontinence and detrusor overactivity. Limited data is available on intravesical treatment with capsaicin and resiniferatoxin. There was one 2007 RCT on 58 women treat with resiniferatoxin, and near was no central treatment effect compare with sham. 13 gain knowledge of in connection with botulinum toxin immunisation psychiatric therapy be noted to extravaganza flawless grades with mostly 60-90% restructuring inwardly symptom; even therefore, maximum of the data is for feminine patients. A of the same nature paucity of data was noted for neuromodulation on mannish patients. The bounded data available show clad glory in man. Autoaugmentation and bowel augmentation are seldom nearly investigational for this sign in neurologically intact patients, but success rates are good (~80%) with tolerable complication rates. Augmentation cystoplasty is also victorious in patients with diminutive dimensions bladders although success rates are noted to be arrange after radiation therapy (Grade C).

The committee stocktaking reports involving 263 patients with rectourethral fistualae and identify numerous surgical approach. The committee made several Grade C recommendations. Surgical closure may be attempt if the fistula do not cover up with or short impermanent urinary and/or fecal diversion. Closure can be done in help with a colorectal surgeon.

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